Umatshini we-FLP-5 we-granulating kunye ne-coating osebenza ngeendlela ezininzi

1. Umgaqo wezixhobo

Umatshini wokomisa nokufaka i-FLP ebhedini emanzi sisixhobo esisebenza ngeendlela ezininzi esidibanisa ukomisa nge-spray, i-granulation, ukwenza iipilisi ze-centrifugal, kunye nokufaka kunye nokomisa nge-fluidized. Lo matshini uyahambelana nemisebenzi eyahlukeneyo yenkqubo.

Beka umgubo we-granulation okanye izinto ze-granular (umgubo) zokugquma ebhedini emanzi. Umoya obandayo ungena kwigumbi lokufudumeza elingasemva komatshini oyintloko uze udlule kwisiphumo sokuqala. Ukucoca okusebenzayo okuphakathi. Isifudumezi sishushu ukuya kubushushu obufunekayo kumoya wokungena uze ungene ebhedini emanzi. Umgubo (ii-granules) uyanyibilikiswa ebhedini. Isibopheleli se-granulation sithunyelwa kwi-atomizer ye-fluid ezimbini ngepompo yokungenisa kwaye sitshizwe kwizinto ze-Fluidized. Ii-powders ziyadibana kwaye zihlangane zibe zii-granules kwaye zikhule okanye zenze ifilimu kwizinto eziza kugqunywa. Emva kokuba amanzi ephumile, akhutshwa ematshinini ngumoya wokukhupha umoya.

Kwibhedi ejikelezayo enyibilikisiweyo, umgubo okanye i-masterbatch ichaphazeleka kukubhabha komoya ojikelezileyo, amandla okujikeleza e-centrifugal kunye nomxhuzulane wayo, kwaye yenza imilo yentambo ejikelezayo. I-binder itshizwa kwizinto ukuze zenze ii-pellets ezine-sphericity ephezulu kakhulu.

Ngokuxhomekeke kumthombo wamandla kunye nohlobo lwe-fluidization, iteknoloji ye-fluidized granulation coating inokwahlulwa ibe ziintlobo ezine:

2. Ububanzi besicelo:

Ifanelekile kwiigranulation, ukwenza iipilisi kunye nokufaka iipeyinti kwiintlobo ngeentlobo kunye neendlela zokulinganisa kumashishini amayeza, ukutya, iikhemikhali kunye namanye amashishini.

● Ukufakwa kwe-granulation kunye nokufakwa kwe-coating yamayeza:

1) Iigranulation: iigranules zokusasaza, iigranules zokufaka iipilisi, izinto ezincedisayo zokufaka ngqo, iigranules zeekhaphu, iigranules zeegranules, kunye neegranules ezahlukeneyo ezinzima.

2) Ukwaleka: iigranules. iipilisi. Iipilisi zigqunyiwe kwaye umgubo awugqunywanga;

● Ukuxubana kwemveliso yokutya: iswekile, ikofu, ikhokho, ijusi ecoliweyo, isitatshi esixutyiweyo, ii-amino acids, izinongo, umgubo wengqolowa, njl.njl.;

● Ukuxubana kwentlama yeswekile: CHC, PVA, MC, HEC, njl.njl.;

● Ukwahlulwa kwezinto ezisetyenziswa kwi-powder;

● Ukwambathisa izinto zomgubo;

● Ukucola izinto ezicoliweyo;

● I-spray granulation kunye ne-coating yamayeza emveli aseTshayina;

● Lungisa iigranule ezinkulu ze-granule eziyi-10-30 ezine-mesh;

● Ugqubuthelo olubhityileyo, olugqunywe ngaphakathi, oluhlala lukhululekile kwiipowders, iigranules, kunye neepilisi;

● Ukufihla incasa, ukumelana nokufuma, ukuthintela ukubola, ukungangeni manzi, ukuthintela ubushushu, ukufaka imibala, ukuvala ukwahlulwahlulwa;

● Izinto ezomileyo eziluthuli, ezirhabaxa nezinamaqhuqhuva;

● Ukwenziwa kwesinyithi ngomgubo kunye ne-granulation yoshishino lwe-ceramic;

● Ukwaluphala kunye nokwambathiswa kwezibulali-zinambuzane, ukutya kunye nezichumisi;

● Ukwaleka kwe-Catalyst granulation;

● Ukwahlulwa kwemibala, izinto ezifaka imibala kunye needayi;

● Ukwahlulwahlulwa kwezinye iikhemikhali eziqhelekileyo.

● Ngokusebenzisa i-powder granulation, ukunyibilika kwayo kuyaphucuka kwaye uthuli luyancitshiswa.

● Ukusebenzisa i-granulation okanye i-coating esezantsi, akukho nkunkuma yezinto zokugquma.

● Futha ngaxeshanye. xuba. Ukuxubana. Iinkqubo zokugquma nezomisa zinciphisa kakhulu iinkqubo zokusebenza.

● Ulwelo oluqinileyo lwemithombo lwenziwa ebhedini ukuqinisekisa ukuba igqunywe ngokulinganayo.

● Inxalenye ephezulu yesixhobo ixhotyiswe ngomngxuma wokunceda, ukuze xa siqhuma, isixhobo singabi nakonakala.

● Ukufaka i-granulating kunye ne-coating kwinkqubo evaliweyo, ngaphandle kokuvuza kunye nokubhabha kothuli.

● Izixhobo zingasebenza ngesandla okanye ngokuzenzekelayo.

● Iiparamitha zenkqubo ye-granulation zizinzile kwaye ukuphindaphindeka kuphezulu kakhulu.

● Izixhobo azinazo iingcinga ezingafunekiyo, zikhutshwa ngokukhawuleza, kulula ukuzihlambulula, kwaye ziyahambelana nemigaqo ye-GMP.

● Hlanganisa imisebenzi emininzi ye-granulation, ukwenza iipilisi kunye nokufaka i-coating kumatshini omnye.

Umatshini wokomisa owomileyo owenziwe ngolwelo ubunjwe kakhulu yinkqubo yokucoca umoya, inkqubo yokufudumeza umoya, inkqubo yokusingatha, inkqubo yokondla kunye ne-atomization, inkqubo yokucoca imveliso kunye nenkqubo yolawulo.

Inkampani yethu idibanisa iteknoloji yamanye amazwe ephucukileyo yokugquma okomileyo yohlobo olufanayo kunye namava asebenzayo aqokelelwe ngabasebenzi bezobugcisa benkampani yethu kwixesha elide. Sifezekise la manqaku alandelayo ngexesha lenkqubo yoyilo:

Ⅰ. Inkqubo yokucoca umoya: Ukucoca umoya kusebenzisa ukucoca okunamanqanaba amabini (isiphumo esiphambili, isiphumo esiphakathi). Kwiimeko ezikhethekileyo, ukucoca okusebenzayo kakhulu kunokusetyenziswa, kwaye umoya unokufikelela kumanqanaba angama-300,000 okucoca.

Ⅱ. Inkqubo yokufudumeza umoya:

Ukufudumeza umoya kuqulathe iityhubhu zokufudumeza zombane, izifudumezi zombane kunye neepayipi zomoya oshushu, njl. Ifanelekile kwiintlobo ngeentlobo zemithombo yobushushu kwaye ingasebenzisa imithombo yobushushu ekhoyo ngexesha langempela ngokweemeko zalapho.

Umzobo wesalathiso sokuhluza kunye nokufudumeza

Ⅲ. Inkqubo yoMsingathi: Inkqubo yoMsingathi ingohlulwa ibe ziziseko, isilinda esezantsi yolwelo lwezinto eziluhlaza, igumbi lokomisa kunye negumbi lokucoca uthuli oluphezulu.

Isiseko: Intloko yesihlalo sevalvu emile okwediski yenza kube lula ukucocwa ngokupheleleyo kwesihlalo sevalvu. Indawo ephantsi ifakwe ivalvu yokukhupha amanzi ezenzekelayo eqhagamshelwe ngendlela yokuvula ngokukhawuleza. Iqhagamshelwe kwizibonelelo ezisecaleni kwaye inoyilo lokuxhoma, okwenza kube lula ukucoca umatshini kunye nenxalenye esezantsi. Itywina eliphakathi kwegumbi elisezantsi kunye necandelo lokuphakamisa liringi yesilicone enamandla efuthwayo.

Isilinda esezantsi yokwenziwa kwe-fluidization yezinto eziluhlaza: Okwangoku kukho iintlobo ezintathu eziphambili zeenkqubo zebhedi enziwe nge-fluidized: i-top spray, i-bottom spray, kunye ne-rotary tangential spray. Ngenxa yezakhiwo ezahlukeneyo zezixhobo, imeko ye-fluidization yezinto nayo yahlukile. Ukusebenzisa iinkqubo ezahlukeneyo, umgangatho we-coating kunye neempawu zokukhululwa kwe-formulation zinokwahluka. Ngokomgaqo, ukuze ifilimu yokwambathisa ifane kwaye iqhubeke, inkqubo nganye kufuneka inciphise ukuhamba kwamaconsi okwambathisa, oko kukuthi, umgama phakathi kwamaconsi ukusuka kwindawo yokuphuma kwe-spray gun ukuya kumphezulu we-substrate, ukuze kuncitshiswe isiphumo sokomisa i-spray somoya oshushu kumaconsi kwaye kwenziwe i-coating Xa ulwelo lwe-coating lufikelela kumphezulu we-substrate, ngokusisiseko lugcina iimpawu zalo zokuqala, kwaye uxinzelelo kunye ne-viscosity azinyuki kakhulu ukuqinisekisa iipropati ezifanelekileyo zokusasaza kunye nokwenza ifilimu kumphezulu we-substrate kwaye zenze ifilimu yokwambathisa efanayo neqhubekayo.

1) Inkqubo yokutshiza esezantsi

Ikwabizwa ngokuba yinkqubo yeWurster, yeyona ndlela iphambili yokusebenzisa i-fluidized bed coating kwaye isetyenziswa kakhulu kwiipellets zokugquma, iigranules, kunye neepowders ezinobukhulu bee-particles ezingaphantsi kwe-50 μm. Kukho i-spacer embindini wetanki yezinto zesixhobo sokutshiza esisezantsi, kunye nepleyiti yokusasaza umoya enemingxuma emininzi emincinci ejikelezayo ezantsi. Ekubeni amazinga okuvula eendawo ezihambelanayo ze-chassis ngaphakathi nangaphandle kwe-spacer ahlukile, kukho isithuba ngaphakathi / ngaphandle kwe-spacer. Ubukhulu bokungena komoya obuhlukeneyo bubangela ukuba amaqhekeza enze iintshukumo eziqhelekileyo ezijikelezayo ngaphakathi nangaphandle kwe-spacer ring. I-spray gun ifakwe ngaphakathi kwe-spacer ring, kwaye i-spray direction iyafana ne-movement direction ye-material. Ke ngoko, indawo ephambili yokugquma ingaphakathi kwe-spacer ring, kwaye indawo ephambili yokumisa ingaphandle kwe-spacer ring. Amaqhekeza adlula kwindawo yokugquma rhoqo emva kwemizuzwana embalwa, egqibezela umjikelo wokugquma. Zonke ii-particles zinethuba elifanayo lokudlula kwindawo yokugquma, ngoko ke ifilimu yokugquma eyenziweyo iyafana kwaye ixinene.

2) Inkqubo yokutshiza i-Tangential

Iteknoloji yokutshiza ethambileyo iyafana neteknoloji yokutshiza ezantsi kwaye ineempawu ezintathu ezifanayo zomzimba: 1) Ukutshiza okumanzi kwicala elinye, isibhamu sokutshiza sifakwe kwizinto, kwaye ukubetheka kwamaconsi okugquma kukufutshane; 2) Amathuba okuba amasuntswana adlule kwindawo yokugquma alingana; 3) Amasuntswana akwindawo yokugquma axinene kakhulu kwaye ukulahleka kolwelo lokutshiza kuncinci. Ngenxa yezi mpawu, umgangatho wefilimu yokugquma eyenziwe ngokutshiza ethambileyo ungcono, olingana nowefilimu yokugquma eyenziwe ngokutshiza ezantsi, kwaye ungasetyenziswa kwiinkqubo zokugquma ezinyibilikayo okanye ze-organic. Umkhombe wesixhobo sokutshiza ethambileyo usi-cylindrical, kunye ne-turntable ehlengahlengiswa ngesantya ezantsi. Kukho umsantsa phakathi kwe-turntable kunye nodonga lwetanki ukuvumela ukuhamba komoya ngaphakathi ukuba kudlule. Ubungakanani bomsantsa buhlengahlengiswa ngokuphakama kwe-turntable ukutshintsha isantya somgca wokuhamba komoya ngaphakathi. Ngenxa yesenzo samandla amathathu: amandla e-centrifugal aveliswa kukujikeleza kwe-turntable, amandla okuqhuba okuhamba komoya ongenayo, kunye nobunzima bamaqhekeza ngokwawo, amaqhekeza ahamba kwimeko ye-spiral centrifugal. I-spray gun ifakwe eludongeni olusecaleni lwetanki yezinto, kwaye icala lokutshiza likwicala elithe tyaba lentshukumo yezinto.

3) Inkqubo yokutshiza ephezulu

I-spray ephezulu isetyenziselwa ikakhulu ukugcoba isisu okanye i-enteric esekwe emanzini, kwaye ngokubanzi ayisetyenziselwa ukukhululwa okuqhubekayo nokulawulwayo. Amasuntswana akwisixhobo sokutshiza esiphezulu aqhutywa kukungena komoya kwaye akhawuleza ukusuka kwitanki yezinto ezisetyenziswayo ukuya kwindawo yokutshiza. Icala lokutshiza le-spray gun lihambelana namasuntswana. Icala lokuhamba lichasene. Emva kokudlula kwindawo yokutshiza, amasuntswana angena kwigumbi lokukhuliswa. Ububanzi begumbi lokukhuliswa bukhulu kunobubanzi begumbi lokutshiza, ngoko ke isantya somsinga womoya siyabuthathaka, kwaye amasuntswana abuyela kwi-pray yezinto ezisetyenziswayo ngenxa yomxhuzulane.

1. Isilinda esiphakathi yinxalenye ebalulekileyo yenkqubo. Inika izinto indawo eyaneleyo yokusasazwa kolwelo olubilayo, nto leyo echaphazela ngokuthe ngqo isiphumo semveliso egqityiweyo. Umjongi ubekwe ngasemva kwegumbi lokusasazwa kolwelo (kubandakanya umjongi weglasi yentsimbi engagqwaliyo) kwaye unokuxhotyiswa nge-spotlight yemizi-mveliso. Isiseko somngxuma kunye nesigqubuthelo ngeenkqubo ezininzi ze-atomization zejethi ezithe nkqo. Isigqubuthelo sokukhulula ngokukhawuleza kulula ukusifaka nokusisusa. Nje ukuba sifakelwe, isigqubuthelo siyagutyungelwa ludonga lwangaphakathi lwesikhongozeli.

2. Umgqomo ophakathi ungaxhotyiswa ngesango lokufunxa imveliso ngokuzenzekelayo. Faka izinto kwibhareli, uvale ivalvu elawula ukuhamba komoya, uze uvule ivalvu yokufunxa. Izinto ziya kuthuthwa ziye kwisikhongozeli sezinto ngevalvu yokondla izinto kwigumbi lokomisa ngesitshizi phantsi koxinzelelo olubi olwenziwe yifeni yokufunxa ephambili (izinto zinikwa phantsi koxinzelelo olubi). Izinto ezikwibhareli zingafakwa nakwisikhongozeli sezinto ngokutsala isikhongozeli somatshini oyintloko (ukutya ngesandla).

Igumbi lesihluzo sokususa uthuli: Iindlela ezahlukeneyo zokususa uthuli kufuneka zisetyenziswe kwizinto ezahlukeneyo zokwenza imveliso ukuze kufumaneke isivuno esikhulu. Ukusebenzisa indlela yokufaka ingxowa yomoya, ingxowa yesihluzo ingaphepha ubunzima bengxowa yesihluzo yangaphambili, enokulungiswa kuphela ngasemva kweflange yegumbi lesihluzo, kwaye ke ngoko ihambelana ngakumbi neemfuno ze-GMP.

Ulwakhiwo oluchasene nokujikeleza kwesibambi sengxowa yesihluzo lunokuthintela ukugqwetheka kwengxowa yokuqokelela okubangelwa kukujikeleza kwesibambi sengxowa yesihluzo, okubangela ukuba ishelufu ifinyezwe, kwaye kuthintele ukuba ingxowa yokuqokelela ingonakali ngenxa yokuphuma kwisilinda. Isakhelo sokuxhoma sesihluzo esakhiwe ngokukodwa siqhagamshelwe kwisixhobo sokungcangcazela. Sinemisebenzi yokukhokela ngokuzenzekelayo kunye nokutshixa, impendulo yesikhashana yesihluzo ekungcangcazelweni kwesilinda iphucula kakhulu iziphumo zokucoca. Igesi yokukhupha umoya inothuli oluncinci. Ukuthintela imeko-bume yangaphandle ekungcolisweni, ukususa uthuli lwenkanyamba (ukhetho) okanye ukususa uthuli lwengxowa kungasetyenziselwa ukuqokelela uthuli kwigesi yokukhupha umoya. Kwaye uthuli oluqokelelweyo lunokuphinda lusetyenziswe.

● Ipompo yokutya ilawulwa ngesandla nangokuzenzekelayo ngesixhobo sokuguqula amaza, kwaye isantya sokondla siyafana.

● Isibhamu sokutshiza esinomoya, isibhamu sokutshiza esisisiseko sentsimbi engatyiwayo/isibhamu sokutshiza esinolwelo oluthathu, njl. Iindidi ezahlukeneyo zezibhamu zokutshiza zinokukhethwa ngokwezixhobo ezahlukeneyo. Zineempawu zobukhulu obuncinci, ubunzima obuphantsi, kulula ukuzicoca nokuzilungisa.

● Isilinda yolwelo: umxube wentsimbi engatyiwayo we-20L/pneumatic, ubungakanani obahlukeneyo kunye neendlela zokuxuba zinokukhethwa ngokwezixhobo ezahlukeneyo. Izixhobo zigcinwa zihamba ngexesha lenkqubo yokuxuba ukuze kuthintelwe ukubola kwezinto kunye nokungalingani.

Inkqubo yoLawulo: Ujongano lomntu nomatshini + ulawulo lwenkqubo ye-PLC lunokusetyenziselwa ukubonisa imeko yokusebenza ngexesha langempela. Idatha yemodyuli yokufaka kunye neyokukhupha iqokelelwa kwi-intanethi. Inkqubo ibonisa ubushushu bolawulo, uxinzelelo, isantya sepompo yezinto, ii-alamu zobushushu obugqithisileyo kunye noxinzelelo olugqithisileyo; iimvume zephasiwedi zisetelwe ukuthintela utshintsho olungalindelekanga. Tshintsha iiparameter ngokungacwangciswanga; ulawulo olufipheleyo lobushushu bomoya wokungena kunye nowokuphuma kunye nempazamo ye-±1°C; Ulawulo lwenkqubo ye-PLC kunye nokutshixa ukuthintela ukusetyenziswa kakubi kwezixhobo kunye nokuqinisekisa ukusebenza ngokukhuselekileyo nangokuzinzileyo kwezixhobo; ikhabhinethi yokulawula ixhotyiswe ngeqhosha lokumisa elingxamisekileyo ukuvumela ukuvalwa kwangoko kwiimeko ezingxamisekileyo.