Muchina weFLP-5 une granulating uye coating unoshanda zvakasiyana-siyana

1. Musimboti wezvishandiso

Muchina wekuomesa nekuputira weFLP une fluidized bed drying and coating muchina une mabasa akawanda unosanganisira spray drying, granulation, centrifugal pills, uye fluidized coating and drying muchina uyu unoshanda nemabasa akasiyana-siyana.

Isa hupfu hwegranulation kana hupfu hwegranular (hupfu) hwekuputira mumubhedha une mvura. Mhepo inotonhora inopinda kubva mukamuri rekudziisa riri kumashure kwemuchina mukuru uye inopfuura nepakati pemhedzisiro yekutanga. Kusefa kwepakati nepakati. Chidziisa chinopisa kusvika patembiricha inodiwa yemhepo inopinza uye yozopinda mumubhedha une mvura. Hupfu (granules) hunonyoroveswa mumubhedha. Chinosunga hupfu hwegranulation chinotumirwa kuatomizer ine mvura mbiri nepombi yeinfusion uye chinopfapfaidzwa kuzvinhu zvine Fluidized. Hupfu hunobatana uye hunoungana kuita granules uye hunokura kana kugadzira firimu pazvinhu zvinoda kuputirwa. Mushure mekunge mvura yapera, inoburitswa mumuchina nemhepo inobuda mumhepo.

Mumubhedha unotenderera, upfu kana kuti masterbatch zvinokanganiswa nekuyerera kwemhepo iri mumhepo, simba rekutenderera kwecentrifugal uye simba rayo rekukwevera pasi, uye zvinoumba chimiro chetambo yakatenderera. Chinosungirirwa chinopfapfaidzwa muchinhu ichi kuti chigadzire mapellets ane sphericity yepamusoro-soro.

Zvichienderana nekwakabva simba uye chimiro chekuyerera kwemvura, tekinoroji yekuputira granulation inogona kukamurwa kuita mhando ina:

2. Chiyero chekushandisa:

Yakakodzera kugadzirwa kwegranulation, kugadzira mapiritsi uye kuputira mhando dzakasiyana-siyana uye mhando dzemuyero muindasitiri yemishonga, chikafu, makemikari nedzimwe nzvimbo.

● Kuputira uye kufukidza mishonga:

1) Zvidimbu: zvidimbu zvekupa, zvidimbu zvekuisa mapiritsi, zvinhu zvinobatsira kubaya zvakananga, zvidimbu zvemakapisiri, zvidimbu zvezvidimbu, uye zvidimbu zvakasiyana-siyana zvinorema.

2)Kuputira: granules. piritsi. Mapiritsi anoputirwa uye upfu hauputirwi;

● Kuumbwa kwezvikamu zveindasitiri yezvekudya: shuga, kofi, koko, muto weupfu, starch yakasanganiswa, amino acids, zvinonhuhwirira, hupfu hwegorosi, nezvimwewo;

● Kuumbwa kweshuga paste: CHC, PVA, MC, HEC, nezvimwewo;

● Kuumbwa kwezvinhu zveupfu;

● Kuputira zvinhu zveupfu;

● Kuchera zvinhu zveupfu;

● Kupfapfaidza nekuisa pendi yemishonga yechivanhu yeChina;

● Gadzirirai granules huru dzine mambure gumi kusvika makumi matatu;

● Pendi yakatetepa, yakaputirwa mukati medumbu, uye inosunungura nguva dzose yehupfu, granules, uye mapiritsi;

● Inovhara kuravira, haipindi hunyoro, haipindi okisijeni, haipindi mvura, inodzivira kupisa, inoisa ruvara, inovhara kupatsanurwa;

● Zvinhu zvakaoma zvakaita seupfu, granular uye mapundu;

● Kugadzira simbi yeupfu uye kugadzira granulation yeindasitiri yeceramic;

● Kuputira nekuvhara mishonga yezvipembenene, zvekudya uye fetereza;

● Kuputira kweCatalyst granulation;

● Kuumbwa kwemavara, zvinhu zvinopenda uye madhayi;

● Kuumbwa kwemamwe makemikari akajairika.

● Kuburikidza nekugadzirwa kweupfu, kuyerera kwemvura kunovandudzwa uye guruva rinoderera.

● Uchishandisa granulation yepurasitiki kana coating yepasi, hapana kutambisa zvinhu zvekuputira.

● Pfapfaidza panguva imwe chete. sanganisa. Kuisa granulation. Maitiro ekuputira nekuomesa anoderedza zvakanyanya mashandiro ekushanda.

● Kunyoroveswa kwemvura mutsime kunogadzirwa pamubhedha kuitira kuti pave nejira rakafanana.

● Chikamu chepamusoro chemuchina chakashongedzwa neburi rekubatsira, kuitira kuti kana chaputika, muchina wacho usakanganiswe.

● Kuputira nekuputira muchimiro chakavharwa, pasina kubuda kwemvura uye guruva richibhururuka.

● Midziyo inogona kushandiswa nemaoko kana otomatiki.

● Magadzirirwo emushonga wegranulation akagadzikana uye kugona kudzokorora kwakakwira zvikuru.

● Midziyo iyi haina magumo asina kunaka, inoburitswa nekukurumidza, inokwenenzverwa nyore nyore, uye inoenderana nezvinodiwa neGMP.

● Batanidza mabasa akasiyana-siyana ekugadzira mapiritsi, kugadzira mapiritsi uye kuaputira mumuchina mumwe chete.

Muchina wekuomesa une mvura yakawanda unonyanya kuumbwa nehurongwa hwekusefa mhepo inopinda, hurongwa hwekudziyisa mhepo, hurongwa hwemugamuchiri, hurongwa hwekudyisa nekugadzira atomization, hurongwa hwekusefa chigadzirwa uye hurongwa hwekudzora.

Kambani yedu inosanganisa tekinoroji yekunze yemhando imwechete yekupenda yakaoma uye ruzivo rwakawanikwa nevashandi vehunyanzvi vekambani yedu kwenguva yakareba. Takawana zvinotevera panguva yekugadzira:

Ⅰ. Sisitimu yekusefa mhepo: Iyo inlet yemhepo inoshandisa kusefa kwematanho maviri (mhedzisiro yekutanga, mhedzisiro yepakati). Mumamiriro ezvinhu akakosha, kusefa kwemagetsi kwakanyanya kunogona kushandiswa, uye mhepo inogona kusvika mazinga 300,000 ekucheneswa.

Ⅱ. Sisitimu yekudziyisa mhepo:

Kudziisa kwemhepo kunosanganisira machubhu emagetsi ekudziisa, mahita emagetsi nemapombi emhepo inopisa, nezvimwewo. Kwakakodzera nzvimbo dzakasiyana-siyana dzekupisa uye kunogona kushandisa nzvimbo dziripo dzekupisa panguva chaiyo zvichienderana nemamiriro enzvimbo yacho.

Dhayagiramu yekutsvaira uye yekudziya

Ⅲ. Sisitimu yeHost: Sisitimu yehost inogona kukamurwa kuita base, raw material fluidizing bottom cylinder, drying chamber uye top dust filter chamber.

Hwaro: Musoro wechigaro chevharuvhu wakaita sedhisiki unobatsira kucheneswa kwechigaro chevharuvhu zvakakwana. Nzvimbo yakaderera ine vharuvhu inoburitsa mvura otomatiki yakabatana nenzira yekuvhura nekukurumidza. Yakabatana nezvitsigiro zvepadivi uye ine dhizaini yekurembera, zvichiita kuti zvive nyore kuchenesa muchina nechikamu chezasi. Chisimbiso chiri pakati pekamuri repasi nechikamu chekusimudza isimbi yakasimba yesilicone inofefeterwa.

Silinda yepasi pemvura inoyerera: Pari zvino kune mhando nhatu huru dzenzira dzemvura dzinoyerera: kupfapfaidza pamusoro, kupfapfaidza pasi, uye kupfapfaidza kwakatenderera. Nekuda kwezvimiro zvakasiyana zvemidziyo, mamiriro emvura inoyerera pazvinhu akasiyanawo. Uchishandisa maitiro akasiyana, mhando yekupenda uye hunhu hwekuburitsa magadzirirwo zvinogona kusiyana. Panyaya iyi, kuti firimu rekupfapfaidza rive rakafanana uye rinoramba riripo, maitiro ese anofanira kuderedza kufamba kwemadonhwe ekupfapfaidza, kureva kuti, daro riri pakati pemadonhwe kubva panobuda pfuti yekupfapfaidza kuenda pamusoro pe substrate, kuitira kuderedza kuomesa kwemhepo inopisa pamadonhwe uye kuita kuti kupfapfaidza kuite. Kana mvura yekupfapfaidza yasvika pamusoro pe substrate, inochengetedza hunhu hwayo hwepakutanga, uye huwandu uye kupenya hazviwedzere zvakanyanya kuti ive nechokwadi chekuti zvinopararira zvakanaka uye zvinogadzira firimu pamusoro pe substrate uye kugadzira firimu rekupfapfaidza rakafanana uye rinoramba riripo.

1) Maitiro ekupfapfaidza pasi

Inozivikanwawo seWurster system, ndiyo nzira huru yekushandisa fluidized bed coating uye yave ichishandiswa zvakanyanya mumapellets ekuputira, magranules, uye kunyange hupfu hune saizi iri pasi pe50 μm. Kune spacer pakati petangi rezvinhu zvechishandiso chekupuruzira pasi, uye ndiro yekugovera mweya ine maburi madiki akawanda akatenderera pasi. Sezvo mwero wekuvhura kwezvikamu zvinoenderana zvechassis mukati nekunze kwespacer wakasiyana, pane gap mukati / kunze kwespacer. Kuwanda kwakasiyana kwemhepo inobuda kunoita kuti zvidimbu zvigadzire kufamba kwakajairika mukati nekunze kwe spacer ring. Pfuti yekupuruzira yakaiswa mukati me spacer ring, uye nzira yekupuruzira yakafanana nenzira yekufamba kwezvinhu. Naizvozvo, nzvimbo huru yekuputira iri mukati me spacer ring, uye nzvimbo huru yekuomesa iri kunze kwe spacer ring. Zvikamu zvinopfuura nepakati pe coating spacer masekondi mashoma ega ega, zvichipedzisa coating-drying cycle. Zvikamu zvese zvine mukana wakafanana wekupfuura nepakati pe coating placer, saka coating film yakagadzirwa yakafanana uye yakakora.

2) Maitiro ekupfapfaidza neTangential

Tekinoroji yekupfapfaidza ine tangential inofananidzwa netekinoroji yekupfapfaidza pasi uye ine hunhu hutatu hwakafanana: 1) Kupfapfaidza kwemvura nenzira imwe chete, pfuti yekupfapfaidza inoiswa muchinhu chacho, uye kurovera kwemadonhwe ekuputira kupfupi; 2) Mikana yekuti zvidimbu zvipfuure nepanzvimbo yekupfapfaidza yakaenzana; 3) Zvikamu zviri munzvimbo yekupfapfaidza zvine simba guru uye kurasikirwa kwemvura yekupfapfaidza kudiki. Nekuda kwehunhu uhwu, mhando yefirimu yekupfapfaidza inoumbwa nekupfapfaidza kwetangential iri nani, iyo yakaenzana neyefirimu yekupfapfaidza inoumbwa nekupfapfaidza pasi, uye inogona kushandiswa kune maitiro ekupfapfaidza emvura kana eorganic solvent. Mugero wechinhu chemudziyo wekupfapfaidza wetangential wakaita sedenderedzwa, une turntable inogadziriswa nekukurumidza pasi. Pane mukaha pakati peturntable nemadziro etangi kuti mweya wekupinda upfuure. Hukuru hwemukaha hunogadziriswa kuburikidza nekukwirira kweturntable kuti uchinje kumhanya kwemhepo inopinda. Nekuda kwekushanda kwemasimba matatu: simba repakati rinogadzirwa nekutenderera kwe turntable, simba rinofambisa mweya unobuda, uye simba rinokweva rezvikamu pachazvo, zvikamu zvinofamba zvakaita se spiral centrifugal state. Pfuti yekupfapfaidza yakaiswa pamadziro eparutivi petangi rezvinhu, uye nzira yekupfapfaidza iri munzira yekufamba kwezvinhu.

3) Maitiro ekupfapfaidza pamusoro

Kupfapfaidza kwepamusoro kunonyanya kushandiswa pakuputira mudumbu kana mudumbu, uye kazhinji hakushandiswi pakuburitsa mweya kwenguva refu uye kunodzorwa. Zvidimbu zviri mumudziyo wekupfapfaidza wepamusoro zvinofambiswa nemhepo inopinza uye zvinokurumidza kubva mutangi rezvinhu zvichipfuura nenzvimbo yekuputira. Kutungamira kwepfuti yekupfapfaidza kunoenderana nezvidimbu. Kutungamira kwekufamba kwakatarisana. Mushure mekupfuura nenzvimbo yekuputira, zvidimbu zvinopinda mukamuri yekuwedzeredza. Dhayamita yekamuri yekuwedzeredza yakakura kupfuura dhayamita yemugero wezvinhu, saka kumhanya kwemhepo kunoderera, uye zvidimbu zvinodzokera mugomba rezvinhu nekuda kwesimba regiravhiti.

1. Silinda yepakati chikamu chakakosha chehurongwa. Inopa zvinhu zvakakwana nzvimbo yekufashaidza mvura inofashaidza, izvo zvinokanganisa zvakananga mashandiro echigadzirwa chapera. Mucherechedzi anoiswa kumashure kwekamuri yekupararira kwemvura inofashaidza (inosanganisira mucherechedzi wegirazi resimbi isina ngura) uye anogona kugadzirirwa chiedza cheindasitiri. Kuisa hwaro hwegomba uye kufukidza nemasisitimu akawanda ejet atomization. Chifukidziro chekusunungura nekukurumidza chiri nyore kuisa nekubvisa. Kana changoiswa, chivharo chinotsvedza nemadziro emukati memudziyo.

2. Bhare repakati rinogona kunge rakashongedzerwa nechinokwevera otomatiki chekukwevera. Isa zvinhu zvacho mubhare, vhara vharuvhu huru inodzora kuyerera kwemhepo, wobva wavhura vharuvhu yekukwevera. Zvinhu izvi zvichaendeswa kumudziyo wezvinhu kuburikidza nevharuvhu yekudyisa zvinhu iri mukamuri rekupfapfaidza pasi pekumanikidzwa kwakashata kunoumbwa nefeni huru yekukwevera (zvinhu izvi zvinopihwa pasi pekumanikidzwa kwakashata). Zvinhu zviri mubhare zvinogonawo kuiswa mumudziyo wezvinhu nekuburitsa mudziyo wemuchina mukuru (kudya nemaoko).

Kamuri rekusefa rekubvisa guruva: Nzira dzakasiyana dzekubvisa guruva dzinofanira kushandiswa pazvinhu zvakasiyana-siyana kuti goho riwedzere. Uchishandisa nzira yekuisa bhegi remhepo, bhegi rekusefa rinogona kudzivirira kuoma kwebhegi rekusefa rekare, iro rinogona kugadziriswa chete kumashure kweflange yekamuri rekusefa, uye nekudaro rinoenderana zvakanyanya nezvinodiwa neGMP.

Chimiro chemubati webhegi refirita chinodzivirira kutenderera chinogona kudzivirira kukanganisa kwebhegi rekuunganidza kunokonzerwa nekutenderera kwemubati webhegi refirita, zvichiita kuti sherufu ipfupike, uye kudzivirira bhegi rekuunganidza kuti risakuvara nekuda kwekubuda kubva musirindiri. Furemu yekumisikidza firita yakarongeka yakabatana nemudziyo wekudzungudza. Iine mabasa ekutungamira otomatiki uye ekukiya, mhinduro yefirita yekudzungudza kwesirinda inovandudza zvakanyanya mhedzisiro yekuchenesa. Gasi rekubudisa utsi rine guruva diki. Kudzivirira nharaunda yekunze kuti isasvibiswe, kubvisa guruva redutu (sarudzo) kana kubvisa guruva rebhegi kunogona kushandiswa kuunganidza guruva kubva mugasi rekubudisa utsi. Uye guruva rakaunganidzwa rinogona kudzokororwa.

● Pombi yekudyisa inodzorwa nemaoko uye otomatiki kuburikidza nechinoshandura mafrequency, uye kumhanya kwekudyisa kwakafanana.

● Pfuti yekupfapfaidza ine atomi, pfuti yekupfapfaidza yesimbi isina ngura/pfuti yekupfapfaidza ine mvura nhatu, nezvimwewo. Mhando dzakasiyana dzepfuti dzekupfapfaidza dzinogona kusarudzwa zvichienderana nezvinhu zvakasiyana. Dzine hunhu hwehukuru hudiki, huremu hushoma, nyore kuchenesa nekugadzirisa.

● Silinda yemvura: bharero resimbi isina ngura 20L/pneumatic mixing, saizi dzakasiyana uye nzira dzekusanganisa zvinogona kusarudzwa zvichienderana nezvinhu zvakasiyana. Zvinhu zvinoramba zvichiyerera panguva yekusanganisa kuitira kudzivirira kusvibiswa kwezvinhu uye kusaenzana.

Sisitimu yekudzora: Kudzora kwepurogiramu yemunhu nemuchina + PLC kunogona kushandiswa kuratidza mamiriro ekushanda panguva chaiyo. Data remuchina wekupinda nekubuda rinounganidzwa online. Sisitimu inoratidza tembiricha yekudzora, kumanikidzwa, kumhanya kwepombi yezvinhu, maalarm ekupisa kwakanyanya uye kumanikidzwa kwakanyanya; mvumo dzepassword dzakaiswa kudzivirira shanduko netsaona. Chinja ma parameters zvisina tsarukano; kudzora tembiricha yemhepo inopinza neyekubuda nekukanganisa kwe ±1°C; Kudzora kwepurogiramu yePLC nekukiya kudzivirira kusashanda zvakanaka kwemidziyo uye kuona kushanda kwakachengeteka uye kwakasimba kwemidziyo; kabhineti yekudzora ine bhatani rekumisa emergency kuti ibvumire kudzima nekukurumidza mumamiriro e emergency.